Pharmaceuticals, Life Sciences, and Biotechnology
Hygienic Mixing, Metering, and Dilution with LEWA Solutions
Special expertise is required in the production of pharmaceuticals in order to ensure that the legal and regulatory requirements are met.
Reliability when it comes to production, documentation, and validation are our top priorities. That's why you can rely on LEWA's tried-and-tested pumps, pump packages and complete systems for many processes in the pharmaceutical, life sciences, and biotechnology industries. Our experts will be happy to advise you on finding optimum, customized solutions for your metering, purification, mixing, and filtration processes.
LEWA hygienic metering pumps (LEWA ecodos and LEWA ecoflow) meet all aseptic requirements in these processes and are always the first choice when it comes to manufacturing low bioburden or even sterile products.
Picture: Buffer inline dilution by means of LEWA hygienic metering pumps or as complete process skid are only one of many solution examples in the pharma and biotech industry.
Inline Dilution, Mixing, Dosing and Other Processes in the Pharmaceutical, Life Sciences, and Biotech Industries
Our systems have in-house engineering and meet all the industry-relevant requirements, such as for inline dilution and dosing (cGMP, GAMP, 21 CFR, etc.). We also offer complete documentation, acceptance tests, validation/qualification, installation, and commissioning services.
System solutions from LEWA can be found in many applications in this market: from the metering of liquids, production of dispersions, homogenization processes at high pressures, various mixing tasks, processes for the dilution of buffers or handling product or concentrates right through to the diverse DSP unit operations. These tasks require precise volume flows and exact conformance with specific process conditions.
|Areas of application for our products and solutions in the pharmaceutical and biotechnology industries||Proportionally mixing sensitive, expensive fluids on a continuous basis||Metering additives for tablet production; tablet coatings, preservatives|
|Precisely adding fluids during the chromatography process||Dosing fluids into the purification process, diluting buffers and concentrates|
|Metering sensitive fluids||Adding enzymes, vitamins, flavorings, and additives for fermentation|
|Aseptically transferring proteins and cells||Adding micro-organisms to fermentations, transferring blood or blood components, transferring products in filling processes|
|Adding additives||Additives, toxic chemicals|
|Injecting fluids for extrusion or spraying mechanisms||Producing active ingredients and tablets, adding stabilizers|
|Microfiltration and ultrafiltration, dialysis systems||Filtering process solutions, carefully concentrating intermediate products (biopharmaceuticals), concentrating and purifying protein solutions, separating cells and particles|
|High-pressure and supercritical applications||Dispersing 2 phases, supercritical processes with CO2, generating nanoparticles|
Solutions for the Pharmaceutical, Life Sciences, and Biotech Industries
The biopharmaceutical, fine chemical, veterinary medicine, and special food supplement industries all require systems that are easy to clean and drain, and that are manufactured and documented according to the applicable guidelines. LEWA has the expertise to design and construct customer-specific systems for these industries.
Our scope of supply for these sectors ranges from simple metering systems for metering additives, dosing modules in process chromatography units and buffer dilution systems, right through to complex systems for the proportional mixing or conveyance of various media.
Process-Integrated Pump Systems for Filtration and Other Processes
We also use the LEWA intellidrive technology to solve difficult metering and conveying tasks:
- Applications that allow a minimum of pulsation such as sensitive chromatography media or fluids during filtration processes
- Highly viscous fluids such as syrup or gel
- Highly precise metering during filling jobs
- Hermetically sealed for hygienic and sterile processes
- Mixing of two fluids in one pump head such as gradient formulation in chromatography processes
- At varying flow rates and at inhomogeneous qualities, changing pressures, or temperatures
Metering Pumps in Hygienic Design
LEWA hygienic metering pumps (LEWA ecodos and LEWA ecoflow) are hermetically sealed, leak-free, and have no connection, such as a shaft, to the product space. This ensures contamination-free metering and conveying over a long process time frame.
Hygienic pumps can also be used as multiplex pumps (e.g., for metering formulas). This means that several pump drive units can be assembled on one drive shaft. The individual pumps then convey varying quantities into the process. To increase the safety of your aseptic and sterile production processes, LEWA hygienic pumps are tested for their cleanability according to recognized, internationally valid guidelines (EHEDG cleanability test and QHD test system).
Advantages at a Glance
High end pumps, equipment and systems
We deliver high-end pumps integrated into complete systems and units for your specific applications. In doing so, we of course rely on the tried-and-tested LEWA quality.
We always deliver economic pumps, systems and units with minimized energy consumption, high efficiency, low maintenance and a long lifetime.
Tried and tested modular system
We design our systems and units in modular design with numerous engine and pump head combinations for different applications.
On request, we can build systems with special materials such as Hastelloy, titanium, duplex stainless steel or further materials. If you are interested, please contact our product manager.
Patented sandwich diaphragm
Our patented diaphragm metering pumps use metal or PTFE sandwich diaphragms with Diaphragm Protection System (DPS) for maximum operational safety.
Sanitary & hygienic design
Highly polished surfaces and a minimal dead space construction are the basis for a system design that meets all the industry's hygienic standards.
Easy to clean
An especially important advantage for pharmaceutical and food industry is that our systems can be quickly and easily cleaned with cleaning chemicals or hot steam.
LEWA pumps, systems and units are compliant with major international standards such as DVGW G280, WHG, PED, ISO 9001, ASME, ATEX and TA-Luft. Of course, you can also define your own standards.
Maintenance and service
No matter if maintenance, spare parts or repair - our service technicians are well trained and available worldwide. Thus, we guarantee fast response and smooth operations.
LEWA systems and gradient mixers are used in downstream processing of chemicals and biotechnology. We look forward to receiving your inquiry!More Details
Caustic soda production
At LEWA, find out about custom plants for producing and diluting different bases like caustic soda. Ask our experts for more information.More Details
Wet oxidation of waste water
For wet oxidation and other processes, we recommend our tried-and-tested LEWA diaphragm pumps. Ask our experts for more information!More Details
Extraction with supercritical fluids
Processes with supercritical fluids in pharmaceutical, food and beverage industries. Ask our experts for more information!More Details
Metering pumps and metering systems must meet the following demands of pharmaceutical production.More Details
Chemical metering in high-pressure cleaning systems
LEWA metering and process diaphragm pumps meet the specific demands for the production of melamine (trimerization of urea). Consult us!More Details
Pharmaceutical spray drying
LEWA provides accurate and efficient diaphragm metering pumps for pharmaceutical spray drying. Consult us!More Details
Production of gelatine
In the production of gelatin and in the fabrication of gelatin products, LEWA pumps and systems are used. We would be happy to give you more information!More Details
High purity systems
Pumps and high purity systems from LEWA are a tried-and-tested solution in the pharmaceutical & biotechnology industry. We are happy to assist with your individual high purity system.More Details
Production of creams
With its metering systems and diaphragm pumps, LEWA offers the right solution for recipe-compliant production of creams.More Details
Metering pumps for sterile applications
LEWA manufactures special aseptic solutions, for the metering of sensitive fluids. Ask our pharma experts for more information!More Details
LEWA ecoflow® diaphragm metering pump
LEWA ecoflow is the innovative and universal metering pump with DPS diaphragm protection system in a tried-and-tested modular system. Suitable for numerous applications, the ecoflow is our real all-around talent, relied on by customers from all industries.More Details
LEWA ecoflow® sanitary/hygienic diaphragm metering pump
LEWA ecoflow is also available in sanitary/hygienic. The metering pump for hygienic applications has the same all-around capabilities and fulfills all specifications for pharmaceutical and food production.More Details
LEWA ecosmart® diaphragm metering pump
LEWA ecosmart is an innovative, compact and multiplexing diaphragm metering pump at a smart price. With it, we of course guarantee our renowned LEWA quality and offer you our expertise derived from 70 years in the market.More Details
LEWA ecodos® mechanical diaphragm metering pump
LEWA ecodos is an absolutely reliable, economical and highly adaptable metering pump, especially where diaphragm actuation is not wanted. Here, we also rely on our tried-and-tested modular system in designing the perfect pump for you.More Details
LEWA ecodos® sanitary/hygienic diaphragm metering pump
A sanitary/hygienic version is also available for the LEWA ecodos. Here, we meet all requirements for operation in pharmaceutical and food production.More Details
LEWA intellidrive® diaphragm metering pump
Design the suction and discharge strokes of the metering pump to meet your specific requirements! With LEWA intellidrive technology, you can model pumping characteristics individually.More Details
LEWA FC laboratory pumps
Metering pumps for very small flow rates. The FC micro-metering pumps for pressures up to 400 bar were developed specifically for laboratories and test centers.More Details
LEWA ecoflow® process pumps for high-pressure applications
The innovative ecoflow diaphragm process pump shows its strengths in high-pressure applications in the oil and gas, refinery and petrochemical industries as well as in the sensitive areas of pharmaceuticals, biotechnology, food and beverage production.More Details
LEWA triplex® process pumps for high-pressure processes
The LEWA triplex process diaphragm pump is among the world's most compact high-pressure pumps and can even be set up in the tightest spaces when space is at a premium. The power package has proven its strength in numerous high-pressure processes in a variety of industries. Oil and Gas icon Gas odor icon gray Refinery icon Petrochemicals icon Chemicals icon Plastics icon gray Cleaning icon Cosmetics icon Pharma icon Food icon Energy icon Other iconMore Details
LEWA Bellows Pulsators
The perfect solution for generating oscillating fluid flows in vertical vessels for a quicker chemical reaction.More Details
Customer-Specific Metering, Mixing or Filling Systems from LEWA
Customer-specific batch/continuous systems for your production process. Metering, mixing, filling, separating, controlling temperature: We work with you to develop the ideal process-related sequence and produce the system that fits your production process – right up to the end product.More Details
Customer-Specific Metering Systems from LEWA
Turnkey metering system in closed loop control with monitoring and plausibility testing equipment. Your individually configured metering system with an optimally designed pump for fluid metering in automated processes.More Details
LEWA triplex® homogenizing pump
The LEWA triplex homogenizing pump offers hermetic diaphragm technology for sensitive ready-to-drink products, infant food, nutraceuticals and enteral nutrition. It is ideally suited for the treatment of demanding fluids in the food, beverage and pharmaceutical industries.More Details
HNPM - Micro annular gear pump series HL
Micro annular gear pumps accomplish conventional micro fluidic tasks effectively and efficiently and open up new technological fields.