LEWA delivers diaphragm metering pumps and complete metering systems to handle all types of downstream processing. Examples include gradient mixers for producing gradients and customized systems for inline dilution of buffers as well as metering stations.
These solutions provide the following advantages:
Areas of application: LEWA metering pumps, metering systems and gradient mixers are used in downstream processing, including in the following areas:
Low- and medium-pressure chromatography, for example
Get in touch today so that we can talk about a strategy for implementing your downstream processing requirements!
Liquid chromatography is the most important part of the purification process and provides a broad range of physical downstream processing methods for separating complex mixtures of substances.
The components to be separated are divided into two phases: The stationary phase in a column and the mobile phase, which flows through the stationary packing (here, liquid).
How does chromatography work?
A mixture of various components of a liquid/gas enter a process of process chromatography. The goal is to purify the mixture (downstream processing). The various separating and chromatography solutions are pumped through the system at various speeds. The interaction between the stationary and mobile phases in the system varies in intensity, causing the mixture of substances to separate. The lower the affinity of a molecule for the stationary phase is, the shorter the time in a chromatography column is, and vice versa.
Why is chromatography so special and important?
The chemical and bioprocess industries have the need to separate one product from a complex mixture and to eliminate impurities. This is an important step in the entire processing chain (downstream processing / cleaning) to produce a product with the required level of purity. Today there exists a broad range of methods that the industry can use to achieve these goals. For many reasons, chromatography is a very special and selective separation method that has been used for decades—primarily in the area of production. First, it can separate complex mixtures with great precision. Even very complicated molecules such as proteins, for instance, can be carefully separated from each other using chromatography. This way, basically any soluble or volatile substance can be purified if the correct adsorbents, carrier fluids / mobile phases are used and provided that process parameters are adapted and monitored (temperature, pH value, flow velocity, conductivity and much more).
Downstream processing is perfect for separating or purifying sensitive products from the pharmaceutical sector specifically.
As the leading manufacturer of pumps and pump systems for the pharmaceutical, life sciences, and biotechnology industries, LEWA supports you during the development of complete solutions, which meet your process requirements exactly. Special expertise is required in the production of pharmaceuticals in order to ensure that legal requirements are met. Reliability when it comes to production, documentation, and validation are our top priorities.More Details
LEWA ecoflow is the innovative and universal metering pump with DPS diaphragm protection system in a tried-and-tested modular system. Suitable for numerous applications, the ecoflow is our real all-around talent, relied on by customers from all industries.More Details
LEWA ecoflow is also available in sanitary/hygienic. The metering pump for hygienic applications has the same all-around capabilities and fulfills all specifications for pharmaceutical and food production.More Details
A sanitary/hygienic version is also available for the LEWA ecodos. Here, we meet all requirements for operation in pharmaceutical and food production.More Details
The innovative ecoflow diaphragm process pump shows its strengths in high-pressure applications in the oil and gas, refinery and petrochemical industries as well as in the sensitive areas of pharmaceuticals, biotechnology, food and beverage production.More Details
Customer-specific batch/continuous systems for your production process. Metering, mixing, filling, separating, controlling temperature: We work with you to develop the ideal process-related sequence and produce the system that fits your production process – right up to the end product.More Details